Interleukin-8 Can Reduce Post-Surgical Lymphedema Formation by Promoting Lymphatic Vessel Regeneration
Identifieur interne : 004215 ( Main/Exploration ); précédent : 004214; suivant : 004216Interleukin-8 Can Reduce Post-Surgical Lymphedema Formation by Promoting Lymphatic Vessel Regeneration
Auteurs : Inho Choi [États-Unis] ; Yong Suk Lee [États-Unis] ; Hee Kyoung Chung [États-Unis] ; Dongwon Choi [États-Unis] ; Tatiana Ecoiffier [États-Unis] ; Ha Neul Lee [États-Unis] ; Kyu Eui Kim [États-Unis] ; Sunju Lee [États-Unis] ; Eun Kyung Park [États-Unis] ; Yong Sun Maeng [États-Unis] ; Nam Yun Kim [États-Unis] ; Robert D. Ladner [États-Unis] ; Nicos A. Petasis [États-Unis] ; Chester J. Koh [États-Unis] ; Lu Chen [États-Unis] ; Heinz-Josef Lenz [États-Unis] ; Young-Kwon Hong [États-Unis]Source :
- Angiogenesis [ 0969-6970 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Cellules endothéliales (), Cellules endothéliales (métabolisme), Complications postopératoires (anatomopathologie), Complications postopératoires (physiopathologie), Complications postopératoires (traitement médicamenteux), Complications postopératoires (étiologie), Développement embryonnaire (), Facteur de nécrose tumorale alpha (pharmacologie), Humains, Inhibiteur p57 de kinase cycline-dépendante (métabolisme), Interleukine-8 (métabolisme), Interleukine-8 (pharmacologie), Interleukine-8 (usage thérapeutique), Lymphangiogenèse (), Lymphoedème (anatomopathologie), Lymphoedème (physiopathologie), Lymphoedème (traitement médicamenteux), Lymphoedème (étiologie), Microenvironnement tumoral (), Néovascularisation physiologique (), Prolifération cellulaire (), Protéines suppresseurs de tumeurs (métabolisme), Protéines à homéodomaine (métabolisme), Récepteurs à l'interleukine-8 (métabolisme), Récepteurs à l'interleukine-8A (métabolisme), Récepteurs à l'interleukine-8B (métabolisme), Régulation négative (), Régénération (), Souris, Souris transgéniques, Trétinoïne (pharmacologie), Vaisseaux lymphatiques (), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (physiopathologie).
- MESH :
- anatomopathologie : Complications postopératoires, Lymphoedème, Vaisseaux lymphatiques.
- métabolisme : Cellules endothéliales, Inhibiteur p57 de kinase cycline-dépendante, Interleukine-8, Protéines suppresseurs de tumeurs, Protéines à homéodomaine, Récepteurs à l'interleukine-8, Récepteurs à l'interleukine-8A, Récepteurs à l'interleukine-8B.
- pharmacologie : Facteur de nécrose tumorale alpha, Interleukine-8, Trétinoïne.
- physiopathologie : Complications postopératoires, Lymphoedème, Vaisseaux lymphatiques.
- traitement médicamenteux : Complications postopératoires, Lymphoedème.
- usage thérapeutique : Interleukine-8.
- étiologie : Complications postopératoires, Lymphoedème.
- Animaux, Cellules cultivées, Cellules endothéliales, Développement embryonnaire, Humains, Lymphangiogenèse, Microenvironnement tumoral, Néovascularisation physiologique, Prolifération cellulaire, Régulation négative, Régénération, Souris, Souris transgéniques, Vaisseaux lymphatiques.
English descriptors
- KwdEn :
- Animals, Cell Proliferation (drug effects), Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p57 (metabolism), Down-Regulation (drug effects), Embryonic Development (drug effects), Endothelial Cells (drug effects), Endothelial Cells (metabolism), Homeodomain Proteins (metabolism), Humans, Interleukin-8 (metabolism), Interleukin-8 (pharmacology), Interleukin-8 (therapeutic use), Lymphangiogenesis (drug effects), Lymphatic Vessels (drug effects), Lymphatic Vessels (pathology), Lymphatic Vessels (physiopathology), Lymphedema (drug therapy), Lymphedema (etiology), Lymphedema (pathology), Lymphedema (physiopathology), Mice, Mice, Transgenic, Neovascularization, Physiologic (drug effects), Postoperative Complications (drug therapy), Postoperative Complications (etiology), Postoperative Complications (pathology), Postoperative Complications (physiopathology), Receptors, Interleukin-8 (metabolism), Receptors, Interleukin-8A (metabolism), Receptors, Interleukin-8B (metabolism), Regeneration (drug effects), Tretinoin (pharmacology), Tumor Microenvironment (drug effects), Tumor Necrosis Factor-alpha (pharmacology), Tumor Suppressor Proteins (metabolism).
- MESH :
- chemical , metabolism : Cyclin-Dependent Kinase Inhibitor p57, Homeodomain Proteins, Interleukin-8, Receptors, Interleukin-8, Receptors, Interleukin-8A, Receptors, Interleukin-8B, Tumor Suppressor Proteins.
- drug effects : Cell Proliferation, Down-Regulation, Embryonic Development, Endothelial Cells, Lymphangiogenesis, Lymphatic Vessels, Neovascularization, Physiologic, Regeneration, Tumor Microenvironment.
- drug therapy : Lymphedema, Postoperative Complications.
- etiology : Lymphedema, Postoperative Complications.
- metabolism : Endothelial Cells.
- pathology : Lymphatic Vessels, Lymphedema, Postoperative Complications.
- chemical , pharmacology : Interleukin-8, Tretinoin, Tumor Necrosis Factor-alpha.
- physiopathology : Lymphatic Vessels, Lymphedema, Postoperative Complications.
- chemical , therapeutic use : Interleukin-8.
- Animals, Cells, Cultured, Humans, Mice, Mice, Transgenic.
Abstract
Lymphedema is mainly caused by lymphatic obstruction and manifested as tissue swelling, often in the arms and legs. Lymphedema is one of the most common post-surgical complications in breast cancer patients and presents a painful and disfiguring chronic illness that has few treatment options. Here, we evaluated the therapeutic potential of interleukin (IL)-8 in lymphatic regeneration independent of its pro-inflammatory activity. We found that IL-8 promoted proliferation, tube formation, and migration of lymphatic endothelial cells (LECs) without activating the VEGF signaling. Additionally, IL-8 suppressed the major cell cycle inhibitor CDKN1C/p57KIP2 by downregulating its positive regulator PROX1, which is known as the master regulator of LEC-differentiation. Animal-based studies such as matrigel plug and cornea micropocket assays demonstrated potent efficacy of IL-8 in activating lymphangiogenesis
Url:
DOI: 10.1007/s10456-012-9297-6
PubMed: 22945845
PubMed Central: 4166493
Affiliations:
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type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Yong Suk" sort="Lee, Yong Suk" uniqKey="Lee Y" first="Yong Suk" last="Lee">Yong Suk Lee</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Chung, Hee Kyoung" sort="Chung, Hee Kyoung" uniqKey="Chung H" first="Hee Kyoung" last="Chung">Hee Kyoung Chung</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Ecoiffier, Tatiana" sort="Ecoiffier, Tatiana" uniqKey="Ecoiffier T" first="Tatiana" last="Ecoiffier">Tatiana Ecoiffier</name><affiliation wicri:level="2"><nlm:aff id="A5">Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Ha Neul" sort="Lee, Ha Neul" uniqKey="Lee H" first="Ha Neul" last="Lee">Ha Neul Lee</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Kyu Eui" sort="Kim, Kyu Eui" uniqKey="Kim K" first="Kyu Eui" last="Kim">Kyu Eui Kim</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Park, Eun Kyung" sort="Park, Eun Kyung" uniqKey="Park E" first="Eun Kyung" last="Park">Eun Kyung Park</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Maeng, Yong Sun" sort="Maeng, Yong Sun" uniqKey="Maeng Y" first="Yong Sun" last="Maeng">Yong Sun Maeng</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Nam Yun" sort="Kim, Nam Yun" uniqKey="Kim N" first="Nam Yun" last="Kim">Nam Yun Kim</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Ladner, Robert D" sort="Ladner, Robert D" uniqKey="Ladner R" first="Robert D." last="Ladner">Robert D. Ladner</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Petasis, Nicos A" sort="Petasis, Nicos A" uniqKey="Petasis N" first="Nicos A." last="Petasis">Nicos A. Petasis</name><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Department of Chemistry, Dornsife College of Letters, Arts & Sciences, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Chemistry, Dornsife College of Letters, Arts & Sciences, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Koh, Chester J" sort="Koh, Chester J" uniqKey="Koh C" first="Chester J." last="Koh">Chester J. Koh</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Pediatric Urology, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Pediatric Urology, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation wicri:level="2"><nlm:aff id="A5">Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Medical Oncology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Medical Oncology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22945845</idno><idno type="pmc">4166493</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166493</idno><idno type="RBID">PMC:4166493</idno><idno type="doi">10.1007/s10456-012-9297-6</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003A64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003A64</idno><idno type="wicri:Area/Pmc/Curation">003A63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003A63</idno><idno type="wicri:Area/Pmc/Checkpoint">002941</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002941</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001F74</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F74</idno><idno 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wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Yong Suk" sort="Lee, Yong Suk" uniqKey="Lee Y" first="Yong Suk" last="Lee">Yong Suk Lee</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Chung, Hee Kyoung" sort="Chung, Hee Kyoung" uniqKey="Chung H" first="Hee Kyoung" last="Chung">Hee Kyoung Chung</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Ecoiffier, Tatiana" sort="Ecoiffier, Tatiana" uniqKey="Ecoiffier T" first="Tatiana" last="Ecoiffier">Tatiana Ecoiffier</name><affiliation wicri:level="2"><nlm:aff id="A5">Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Ha Neul" sort="Lee, Ha Neul" uniqKey="Lee H" first="Ha Neul" last="Lee">Ha Neul Lee</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Kyu Eui" sort="Kim, Kyu Eui" uniqKey="Kim K" first="Kyu Eui" last="Kim">Kyu Eui Kim</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Park, Eun Kyung" sort="Park, Eun Kyung" uniqKey="Park E" first="Eun Kyung" last="Park">Eun Kyung Park</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Maeng, Yong Sun" sort="Maeng, Yong Sun" uniqKey="Maeng Y" first="Yong Sun" last="Maeng">Yong Sun Maeng</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Kim, Nam Yun" sort="Kim, Nam Yun" uniqKey="Kim N" first="Nam Yun" last="Kim">Nam Yun Kim</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Ladner, Robert D" sort="Ladner, Robert D" uniqKey="Ladner R" first="Robert D." last="Ladner">Robert D. Ladner</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Pathology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Pathology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Petasis, Nicos A" sort="Petasis, Nicos A" uniqKey="Petasis N" first="Nicos A." last="Petasis">Nicos A. Petasis</name><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6">Department of Chemistry, Dornsife College of Letters, Arts & Sciences, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Chemistry, Dornsife College of Letters, Arts & Sciences, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Koh, Chester J" sort="Koh, Chester J" uniqKey="Koh C" first="Chester J." last="Koh">Chester J. Koh</name><affiliation wicri:level="2"><nlm:aff id="A7">Division of Pediatric Urology, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Pediatric Urology, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation wicri:level="2"><nlm:aff id="A5">Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Center of Eye Disease and Development, Program in Vision Science, and School of Optometry, University of California, Berkeley</wicri:cityArea></affiliation></author><author><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Medical Oncology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Division of Medical Oncology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author><author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Department of Surgery, Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea></affiliation></author></analytic><series><title level="j">Angiogenesis</title><idno type="ISSN">0969-6970</idno><idno type="eISSN">1573-7209</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Proliferation (drug effects)</term><term>Cells, Cultured</term><term>Cyclin-Dependent Kinase Inhibitor p57 (metabolism)</term><term>Down-Regulation (drug effects)</term><term>Embryonic Development (drug effects)</term><term>Endothelial Cells (drug effects)</term><term>Endothelial Cells (metabolism)</term><term>Homeodomain Proteins (metabolism)</term><term>Humans</term><term>Interleukin-8 (metabolism)</term><term>Interleukin-8 (pharmacology)</term><term>Interleukin-8 (therapeutic use)</term><term>Lymphangiogenesis (drug effects)</term><term>Lymphatic Vessels (drug effects)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphatic Vessels (physiopathology)</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Lymphedema (physiopathology)</term><term>Mice</term><term>Mice, Transgenic</term><term>Neovascularization, Physiologic (drug effects)</term><term>Postoperative Complications (drug therapy)</term><term>Postoperative Complications (etiology)</term><term>Postoperative Complications (pathology)</term><term>Postoperative Complications (physiopathology)</term><term>Receptors, Interleukin-8 (metabolism)</term><term>Receptors, Interleukin-8A (metabolism)</term><term>Receptors, Interleukin-8B (metabolism)</term><term>Regeneration (drug effects)</term><term>Tretinoin (pharmacology)</term><term>Tumor Microenvironment (drug effects)</term><term>Tumor Necrosis Factor-alpha (pharmacology)</term><term>Tumor Suppressor Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cellules endothéliales ()</term><term>Cellules endothéliales (métabolisme)</term><term>Complications postopératoires (anatomopathologie)</term><term>Complications postopératoires (physiopathologie)</term><term>Complications postopératoires (traitement médicamenteux)</term><term>Complications postopératoires (étiologie)</term><term>Développement embryonnaire ()</term><term>Facteur de nécrose tumorale alpha (pharmacologie)</term><term>Humains</term><term>Inhibiteur p57 de kinase cycline-dépendante (métabolisme)</term><term>Interleukine-8 (métabolisme)</term><term>Interleukine-8 (pharmacologie)</term><term>Interleukine-8 (usage thérapeutique)</term><term>Lymphangiogenèse ()</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (physiopathologie)</term><term>Lymphoedème (traitement médicamenteux)</term><term>Lymphoedème (étiologie)</term><term>Microenvironnement tumoral ()</term><term>Néovascularisation physiologique ()</term><term>Prolifération cellulaire ()</term><term>Protéines suppresseurs de tumeurs (métabolisme)</term><term>Protéines à homéodomaine (métabolisme)</term><term>Récepteurs à l'interleukine-8 (métabolisme)</term><term>Récepteurs à l'interleukine-8A (métabolisme)</term><term>Récepteurs à l'interleukine-8B (métabolisme)</term><term>Régulation négative ()</term><term>Régénération ()</term><term>Souris</term><term>Souris transgéniques</term><term>Trétinoïne (pharmacologie)</term><term>Vaisseaux lymphatiques ()</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (physiopathologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclin-Dependent Kinase Inhibitor p57</term><term>Homeodomain Proteins</term><term>Interleukin-8</term><term>Receptors, Interleukin-8</term><term>Receptors, Interleukin-8A</term><term>Receptors, Interleukin-8B</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Complications postopératoires</term><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Down-Regulation</term><term>Embryonic Development</term><term>Endothelial Cells</term><term>Lymphangiogenesis</term><term>Lymphatic Vessels</term><term>Neovascularization, Physiologic</term><term>Regeneration</term><term>Tumor Microenvironment</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term><term>Inhibiteur p57 de kinase cycline-dépendante</term><term>Interleukine-8</term><term>Protéines suppresseurs de tumeurs</term><term>Protéines à homéodomaine</term><term>Récepteurs à l'interleukine-8</term><term>Récepteurs à l'interleukine-8A</term><term>Récepteurs à l'interleukine-8B</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Interleukine-8</term><term>Trétinoïne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interleukin-8</term><term>Tretinoin</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Complications postopératoires</term><term>Lymphoedème</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Interleukin-8</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications postopératoires</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Interleukine-8</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Complications postopératoires</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Humans</term><term>Mice</term><term>Mice, Transgenic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cellules endothéliales</term><term>Développement embryonnaire</term><term>Humains</term><term>Lymphangiogenèse</term><term>Microenvironnement tumoral</term><term>Néovascularisation physiologique</term><term>Prolifération cellulaire</term><term>Régulation négative</term><term>Régénération</term><term>Souris</term><term>Souris transgéniques</term><term>Vaisseaux lymphatiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Lymphedema is mainly caused by lymphatic obstruction and manifested as tissue swelling, often in the arms and legs. Lymphedema is one of the most common post-surgical complications in breast cancer patients and presents a painful and disfiguring chronic illness that has few treatment options. Here, we evaluated the therapeutic potential of interleukin (IL)-8 in lymphatic regeneration independent of its pro-inflammatory activity. We found that IL-8 promoted proliferation, tube formation, and migration of lymphatic endothelial cells (LECs) without activating the VEGF signaling. Additionally, IL-8 suppressed the major cell cycle inhibitor CDKN1C/p57<sup>KIP2</sup> by downregulating its positive regulator PROX1, which is known as the master regulator of LEC-differentiation. Animal-based studies such as matrigel plug and cornea micropocket assays demonstrated potent efficacy of IL-8 in activating lymphangiogenesis <italic>in vivo</italic>. Moreover, we have generated a novel transgenic mouse model (K14-hIL8) that expresses human IL-8 in the skin and then crossed with lymphatic-specific fluorescent (Prox1-GFP) mouse. The resulting double transgenic mice showed that a stable expression of IL-8 could promote embryonic lymphangiogenesis. Moreover, an immunodeficient IL-8-expressing mouse line that was established by crossing K14-hIL8 mice with athymic nude mice displayed an enhanced tumor-associated lymphangiogenesis. Finally, when experimental lymphedema was introduced, K14-hIL8 mice showed an improved amelioration of lymphedema with an increased lymphatic regeneration. Together, we report that IL-8 can activate lymphangiogenesis <italic>in vitro</italic> and <italic>in vivo</italic> with a therapeutic efficacy in post-surgical lymphedema.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Choi, Inho" sort="Choi, Inho" uniqKey="Choi I" first="Inho" last="Choi">Inho Choi</name></region><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name><name sortKey="Choi, Inho" sort="Choi, Inho" uniqKey="Choi I" first="Inho" last="Choi">Inho Choi</name><name sortKey="Chung, Hee Kyoung" sort="Chung, Hee Kyoung" uniqKey="Chung H" first="Hee Kyoung" last="Chung">Hee Kyoung Chung</name><name sortKey="Chung, Hee Kyoung" sort="Chung, Hee Kyoung" uniqKey="Chung H" first="Hee Kyoung" last="Chung">Hee Kyoung Chung</name><name sortKey="Ecoiffier, Tatiana" sort="Ecoiffier, Tatiana" uniqKey="Ecoiffier T" first="Tatiana" last="Ecoiffier">Tatiana Ecoiffier</name><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name><name sortKey="Kim, Kyu Eui" sort="Kim, Kyu Eui" uniqKey="Kim K" first="Kyu Eui" last="Kim">Kyu Eui Kim</name><name sortKey="Kim, Kyu Eui" sort="Kim, Kyu Eui" uniqKey="Kim K" first="Kyu Eui" last="Kim">Kyu Eui Kim</name><name sortKey="Kim, Nam Yun" sort="Kim, Nam Yun" uniqKey="Kim N" first="Nam Yun" last="Kim">Nam Yun Kim</name><name sortKey="Kim, Nam Yun" sort="Kim, Nam Yun" uniqKey="Kim N" first="Nam Yun" last="Kim">Nam Yun Kim</name><name sortKey="Koh, Chester J" sort="Koh, Chester J" uniqKey="Koh C" first="Chester J." last="Koh">Chester J. Koh</name><name sortKey="Ladner, Robert D" sort="Ladner, Robert D" uniqKey="Ladner R" first="Robert D." last="Ladner">Robert D. Ladner</name><name sortKey="Ladner, Robert D" sort="Ladner, Robert D" uniqKey="Ladner R" first="Robert D." last="Ladner">Robert D. Ladner</name><name sortKey="Lee, Ha Neul" sort="Lee, Ha Neul" uniqKey="Lee H" first="Ha Neul" last="Lee">Ha Neul Lee</name><name sortKey="Lee, Ha Neul" sort="Lee, Ha Neul" uniqKey="Lee H" first="Ha Neul" last="Lee">Ha Neul Lee</name><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name><name sortKey="Lee, Yong Suk" sort="Lee, Yong Suk" uniqKey="Lee Y" first="Yong Suk" last="Lee">Yong Suk Lee</name><name sortKey="Lee, Yong Suk" sort="Lee, Yong Suk" uniqKey="Lee Y" first="Yong Suk" last="Lee">Yong Suk Lee</name><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name><name sortKey="Lenz, Heinz Josef" sort="Lenz, Heinz Josef" uniqKey="Lenz H" first="Heinz-Josef" last="Lenz">Heinz-Josef Lenz</name><name sortKey="Maeng, Yong Sun" sort="Maeng, Yong Sun" uniqKey="Maeng Y" first="Yong Sun" last="Maeng">Yong Sun Maeng</name><name sortKey="Maeng, Yong Sun" sort="Maeng, Yong Sun" uniqKey="Maeng Y" first="Yong Sun" last="Maeng">Yong Sun Maeng</name><name sortKey="Park, Eun Kyung" sort="Park, Eun Kyung" uniqKey="Park E" first="Eun Kyung" last="Park">Eun Kyung Park</name><name sortKey="Park, Eun Kyung" sort="Park, Eun Kyung" uniqKey="Park E" first="Eun Kyung" last="Park">Eun Kyung Park</name><name sortKey="Petasis, Nicos A" sort="Petasis, Nicos A" uniqKey="Petasis N" first="Nicos A." last="Petasis">Nicos A. Petasis</name><name sortKey="Petasis, Nicos A" sort="Petasis, Nicos A" uniqKey="Petasis N" first="Nicos A." last="Petasis">Nicos A. Petasis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
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Ou
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Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
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|clé= PMC:4166493
|texte= Interleukin-8 Can Reduce Post-Surgical Lymphedema Formation by Promoting Lymphatic Vessel Regeneration
}}
Pour générer des pages wiki
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